comparative study on efficacy of chlorthalidone and azilsartan in confirmed cases of hypertension associated with ace gene polymorphism

The angiotensin-converting enzyme (ACE) gene consists of 26 exons, it is located on chromosome 17 and its polymorphism a major contributing factor to hypertension. aim compare the efficacy Chlorthalidone Azilsartan in newly diagnosed hypertension patients association with ACE polymorphism. study was conducted department pharmacology, Rama medical college, Kanpur. After doing genetic test basic investigation, 90 associated were recruited, followed by grouping into two A&B. Group-A(n=45) given 45mg/day group-B(n=45) 25mg/day for 3 months. Systolic diastolic blood pressure (SBP& DBP) measured before after months treatment both groups they compared. Three genotypes found polymorphism-associated cases such as I/I, I/D D/D, severity more D/D genotype I/I genotypes. All three group-A & B had shown significant mean reduction SBP& DBP (p<0.05) but high then genotype.